Phytosterols

PHYTOSTEROLS

PRODUCT CODE: N/P/0417
APPEARANCE OFF WHITE COLOURED POWDER
BETA-SITOSTEROL MIN 40%
CAMPESTEROL MIN 20%
STIGMASTEROL MIN 15%
BRASSICASTEROL MIN 0.5%
TOTAL SITOSTEROLS MIN 90%
MELTING POINT 135 145&degC
HEAVY METALS MAX 0.001%
ARSENIC MAX. 0.0005%
CHLORIDE MAX 0.1%
SULPHATE MAX. 0.2%
ASH MAX. 0.2%
LOSS ON DRYING MAX. 3.0%
TOTAL PLATE COUNT MAX 3000 CFU/G
E-COLI MAX 10 CFU/G
SALMONELLA NEGATIVE

Description : Phytosterols, or plant sterols, are a family of molecules related to cholesterol. They are found in the cell membranes of plants, where they play important roles, just like cholesterol in humans. The most common phytosterols in the human diet are campesterol, sitosterol and stigmasterol.

Phytosterols are compounds found in plants that resemble cholesterol. The National Institutes of Health report that there are over 200 different phytosterols, and the highest concentrations of phytosterols are found naturally in vegetable oils, beans and nuts. Their benefits are so recognized that foods are being fortified with phytosterols. At the supermarket, you may see orange juice or margarine advertising phytosterol contents. After reviewing the health benefits, you may want to add phytosterol-rich foods to your diet.

Uses : For individuals who seek to naturally lower Total Cholesterol and LDL Cholesterol without side effects or health risks. CHOLOX RX can be used effectively in conjunction with or independent from cholesterol-lowering prescription medications. As with any cholesterol reduction regime, CHOLOX RX is most effective when part of a high-fiber diet containing reduced levels of cholesterol and saturated fat.

Phytosterols, besides hypocholesterolemic effect, present anti-inflammatory properties. Little information is available about their efficacy in Inflammatory Bowel Disease (IBD). Therefore, we have evaluated the effect of a mixture of phytosterols on prevention/induction/remission in a murine experimental model of colitis. Phytosterols were administered x os before, during and after colitis induction with Dextran Sodium Sulfate (DSS) in mice. Disease Activity Index (DAI), colon length, histopathology score, 18 F-FDG microPET, oxidative stress in the intestinal tissue (ileum and colon) and gallbladder ileum and colon spontaneous and carbachol (CCh) induced motility, plasma lipids and plasma, liver and biliary bile acids (BA) were evaluated. A similar longitudinal study was performed in a DSS colitis control group. Mice treated with DSS developed severe colitis as shown by DAI, colon length, histopathology score, 18 F-FDG microPET, oxidative stress. Both spontaneous and induced ileal and colonic motility were severely disturbed. The same was observed with gallbladder. DSS colitis resulted in an increase in plasma cholesterol, and a modification of the BA pattern. Phytosterols feeding did not prevent colitis onset but significantly reduced the severity of the disease and improved clinical and histological remission. It had strong antioxidant effects, almost restored colon, ileal and gallbladder motility. Plasmatic levels of cholesterol were also reduced. DSS induced a modification in the BA pattern consistent with an increase in the intestinal BA deconjugating bacteria, prevented by phytosterols. Phytosterols seem a potential nutraceutical tool for gastrointestinal inflammatory diseases, combining metabolic systematic and local anti-inflammatory effects